For years, most facial rejuvenation treatments focused on fillers that added volume here and softened lines there. And while fillers still work beautifully, today’s clients want something more realistic: results that look natural, feel natural, and actually improve the skin from within, not just cover up signs of ageing. As a result, the world of aesthetics has shifted. People now look for treatments that repair, rebuild, and regenerate their skin, not just temporarily smooth it. That’s where Multilayer Dermifying Beautification comes in.

It’s an advanced, science-backed facial treatment that works across all layers of the face, restoring shape, support, glow, and skin health simultaneously. Instead of treating just one issue (like wrinkles or volume loss), this approach combines hyaluronic acid (HA) fillers with polynucleotides (Soft Nucleofill) to rebuild the face more comprehensively.

This protocol is now used around the world and is also available at Proalign Face & Smile Clinic, as it goes far beyond fillers. It delivers improvements that earlier techniques couldn’t. Let’s break everything down in simple language.

Understanding Why the Face Ages: A Layered Story

Ageing doesn’t start only on the skin’s surface. The entire face changes over time, skin, fat, bone, muscles, everything.

Intrinsic Ageing (Your Internal Clock)

This is the natural ageing that happens inside our bodies due to:

• Slower metabolism
• Hormonal shifts
• Build-up of oxidative damage
• Reduced collagen and elastin

As a result, deeper layers, such as fat pads and even bone, gradually shrink or shift.

Extrinsic Ageing (Environmental Damage)

This type of ageing happens from outside forces like:

• Sun exposure
• Pollution
• Smoking
• Poor diet
• Stress

This causes the skin to become thinner, duller, less firm, and more prone to wrinkles and sagging.

Ageing Grades Explained Simply

• Grade 0–1: Early signs, small changes
• Grade 2: First noticeable volume loss
• Grade 3: Sagging, deeper folds
• Grade 4: Major volume loss and skin laxity

Knowing the “grade” helps design the right treatment plan.

The Science Behind the Power Duo: Polynucleotides + Hyaluronic Acid Fillers

Polynucleotides (Soft Nucleofill): Skin Regeneration Made Simple

Polynucleotides (or PDRNs) are tiny DNA fragments that tell your skin cells to “wake up” and start repairing themselves.

How They Work

They activate special receptors in different layers of the face:

• Skin layer: Boost collagen, reduce inflammation
• Fat layer: Support and protect fat pads
• Muscle/bone area: Improve cell energy and repair

Benefits of the Soft Nucleofill

• Better collagen
• More hydration
• Smoother texture
• More elasticity
• Healthier skin tone
• Stronger fat pads (less hollowness)

Types of Soft Nucleofill

• Soft: Works on the skin surface for glow and texture
• Strong: Works deeper for lift and structural support.

Why the Combination Works So Well

Think of fillers and polynucleotides as two teammates with completely different strengths. Fillers are great at lifting and shaping. Polynucleotides are amazing at repairing and regenerating.

When you put them together, they don’t just add their benefits; they multiply each other’s effects. That’s why this approach feels more like rejuvenation and less like “getting filler”.

Together, they create:

• Immediate lift

This is the part everyone loves; you see a difference right away. Fillers restore the curves and support that ageing slowly erased, especially in the cheeks and midface. Multilayer Dermifying Beautification, like giving your facial structure a gentle “lift” without anything looking stiff.

• Gradual tightening

While the fillers give you instant shape, the polynucleotides start working quietly in the background. Over the next few weeks, your skin becomes firmer and springier as collagen builds up. People often say they look better each week without doing anything new.

• Better collagen

Collagen is basically your skin’s “anti-ageing protein”, and polynucleotides help your body make more of it and make it better. Stronger collagen means firmer, bouncier, more youthful-looking skin. It also helps your filler results hold up beautifully over time.

• Healthier fat pads

One thing many people don’t realise: our facial fat pads shrink as we age, creating hollow areas. Polynucleotides help protect and energise these fat pads, so they stay fuller for longer. This is a big reason the face looks naturally youthful rather than artificially plumped.

• Brighter skin

As your skin becomes healthier, it automatically looks more radiant. Hydration improves, dullness fades, and that “tired” look starts to disappear. It’s the kind of glow people notice but can’t quite put their finger on.

• Softer lines

Fine lines smooth out because the treatment works from both directions. Fillers support the skin from underneath, while polynucleotides repair the surface. The result isn’t a frozen look but a softer, more refreshed version of your natural expressions. Your makeup sits better, and your skin feels nicer, too.

• Natural-looking balance

Because every layer of the face is treated in harmony, nothing sticks out or looks “overdone”. The face still looks like you, just more lifted, smoother, brighter, and well-rested. It’s the balance between Multilayer Dermifying Beautification and skin health that makes this approach so believable.

How the Multilayer Protocol Is Performed

The treatment starts deep and moves layer by layer.

1. Deep Structural Layer (Near the Bone)

A particular filler rebuilds lost support and restores cheek shape. This step recreates the “pillars” of the face that naturally weaken with age. By strengthening the bone-level foundation, the midface automatically looks more lifted and youthful. It also prevents the lower face from sagging or looking heavy, because the support comes from deep within.

2. Deep Fat Compartments

Fillers lift the midface and soften jowling. These deeper fat pads often shrink or slide down as we age, changing facial shape. Restoring volume here helps bring back natural curves and smooths the transition between the cheeks and jawline. It also reduces early sagging, creating a subtle lift without overfilling the surface.

3. Superficial Fat Compartments

A special filler is used to smooth folds and refine facial contours. This layer focuses on the “finishing touches” that give the face a well-blended, soft look. Small dips, lines, and uneven areas are corrected to make everything look seamless from the outside. It ensures there are no harsh edges or overfilled looks, just smooth, refined transitions across the face.

4. Mid-Dermis (Skin Layer)

Soft Nucleofill brightens, hydrates, and improves skin texture. This is where the regeneration truly begins, helping the skin behave more youthfully. It boosts collagen, improves elasticity, and helps the skin retain moisture. Over time, the skin looks smoother, healthier, and naturally radiant.

5. Hypodermis (Fat Layer)

The soft Nucleofill strongly supports deeper tissues and improves natural fullness. This step helps protect the fat pads that normally shrink with age, keeping the face from looking hollow. It encourages healthy tissue function, improving firmness from within. By reinforcing these deeper layers, it also helps the fillers’ results last longer and remain more stable.

Customisation Based on Ageing Severity

Grade 1–2 Ageing: Light volume + skin regeneration

These are early signs of ageing—slight hollowness, fine lines, or mild skin dullness. Treatment here focuses more on prevention and subtle improvements rather than major reshaping. Small amounts of filler restore gentle contours, while polynucleotides boost glow, hydration, and collagen. The goal is to keep the face looking fresh and youthful without any visible changes.

Grade 3 Ageing: Deeper volume, lift + polynucleotides

At this stage, people usually notice dropping cheeks, deeper folds, and early sagging. The protocol uses stronger, deeper fillers to rebuild the midface and support the lower face. Polynucleotides help tighten the skin and restore vitality, improving both structure and texture. This combination gives a noticeable lift while still looking very natural.

Grade 4 Ageing: Multi-session, comprehensive rebuild

This level shows significant hollowing, deep wrinkles, and major loss of support. Treatment is done in stages to avoid overfilling and to allow tissues to regenerate properly. Deep structural fillers, fat pad support, and dermal regeneration work together to rebuild the face layer by layer. Results develop gradually but dramatically, creating a balanced, more youthful shape and healthier skin.

Long-Term Benefits of Multilayer Dermifying Beautification

The Multilayer Dermifying Beautification protocol isn’t just about looking good right after treatment; it’s designed to help the face age better over time. Because it strengthens deeper tissues and boosts natural skin function, the improvements continue developing in the months that follow.

Structural Benefits

When the deeper layers of the face are reinforced, everything above them sits more securely and naturally. This reduces the heaviness that can appear around the mouth and jawline as we age. The overall facial shape becomes more defined, giving a refreshed and lifted appearance without looking overdone.

Skin Benefits

With improved hydration, the skin becomes softer, plumper, and more elastic. Fine lines appear less obvious because the skin holds water better and reflects light more evenly. Over time, the complexion looks brighter and more revitalised, even without makeup.

Biological Benefits

The treatment encourages the skin to work like younger skin, repairing itself more efficiently. Increased collagen means firmer, more resilient tissue that holds its shape better. This slows the appearance of future signs of ageing and supports the longevity of the results.

Aftercare & Safety

The procedure is generally well-tolerated, with minimal downtime. Most people can resume daily activities shortly after treatment.

Common aftercare recommendations:

• Mild swelling is possible: usually settles within a day or two.
• Avoid heavy workouts for 24 hours to help reduce swelling and allow the fillers to settle.
• Use SPF: protects the skin and supports healing.
• Follow-up as advised: ensures the best long-term outcome through proper assessment.

The products used, both fillers and polynucleotides, are biocompatible and designed to work safely with the body’s natural processes. Multilayer Dermifying Beautification have a strong safety record when used correctly.

Myth vs. Fact

Myth 1: “This is just another type of filler.”

Fact: Nope, it’s far more than filling lines. Fillers give structure, yes, but the real star here is polynucleotides, which regenerate your skin, fat pads, and deeper tissues. You’re not just adding volume; you’re improving the skin’s biology.

Myth 2: “It will make my face look puffy or overdone.”

Fact: The whole point of this protocol is to avoid that look. Because every layer is treated in harmony, your face stays balanced, lifted, and natural. No pillow face. No stiffness. Just a fresher version of you.

Myth 3: “Results show instantly.”

Fact: You do get an immediate lift thanks to fillers, but the real magic happens slowly. Polynucleotides take weeks to build collagen, strengthen tissues, and brighten the skin. You don’t look suddenly different; you look gradually better.

Myth 4: “It hurts a lot because so many layers are injected.”

Fact: Not true! Most clients are surprised by how comfortable it feels. Numbing cream, fine needles, and gentle techniques make it very tolerable. It’s more “pressure and tiny pinches” than pain.

Myth 5: “Once I do it, I’ll have to keep doing it forever.”

Fact: Maintenance is optional, not mandatory. Because this treatment rebuilds support and improves tissue quality, many clients need fewer touch-ups over time. Your skin becomes stronger, not dependent.

Myth 6: “People will immediately know I got something done.”

Fact: They’ll notice you look good, not ‘done.’ Expect comments like:

• Did you sleep well?
• Your skin looks amazing!
• Did you change your skincare routine?

It’s subtle and believable, not dramatic.

Myth 7: “It’s only for older people.”

Fact: It’s actually fantastic for prevention. Anyone 25+ can benefit from collagen stimulation, hydration, and tissue support. Starting early helps you age more gracefully and need less correction later.

Who Is a Good Candidate?

This protocol is suitable for a wide range of people because it adapts to different ageing stages and facial needs.

Ideal candidates include:

• Anyone 25+ with early or moderate ageing: great for prevention and gentle correction.
• People who want natural-looking results: perfect for those avoiding exaggerated or “filled” appearances.
• Individuals noticing hollowness, dull skin, or sagging: helps restore volume, luminosity, and support.
• Anyone wanting preventative ageing care: strengthens tissues early to slow down future ageing changes.

Experience the Future of Facial Rejuvenation at Proalign Face & Smile Clinic.

Multilayer Dermifying Beautification represents a new chapter in aesthetic medicine, one that combines structure and regeneration for results that look fresh, elegant, and long-lasting. By treating every layer of the face, it restores harmony and gives natural rejuvenation without changing your expressions or identity. If you’re ready to explore a regenerative, customised approach to facial rejuvenation, Proalign Face & Smile Clinic can guide you through every step with expertise and care.